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Mechanical allodynia (other pain) is a painful sensation caused by innocuous stimuli like light touch. Unlike inflammatory hyperalgesia that has a protective role, allodynia has no obvious ... Two new papers show that Piezo2, the mechanosensitive ion channel that brings about the sensations of gentle touch, vibration, and proprioception, also triggers tactile allodynia in mice and humans, but is not required for sensing other types of noxious mechanical stimuli such as pinch or pinprick ... Because allodynia is an evoked pain, testing requires an external stimulation of non-painful quality. Mainly three different types of stimulation have been used to test allodynia in animal models of neuropathic pain: mechanical touch, cold, and air blow.
Mechanical allodynia (other pain) is a painful sensation caused by innocuous stimuli like light touch. Unlike inflammatory hyperalgesia that has a protective role, allodynia has no obvious ... May 23, 2018 · Migraines are more than headaches. They can make your nerves so sensitive that even the slightest touch hurts. This is called allodynia. You can prevent allodynia by treating migraine symptoms as ... Mechanical allodynia (pain) can result from innocuous stimuli such as light touch (Lolignier, Eijkelkamp, & Wood, 2015). Since mechanical allodynia is associated with the cAMP messenger pathway mediated by the protein EPAC1, the connection between Piezo2 and this pathway was examined ( Eijkelkamp, Linley, et al., 2013 ).