The absorption of red cells from the peritoneal cavity of fetal lambs was studied in 29 pregnant ewes at approximately 120 days' gestation. Onset of absorption was early, absorption was rapid, and virtually complete absorption was shown in 96% of the fetuses by 92 hours after intrauterine transfusion.
Intrauterine Transfusion (IUT) is a procedure in which blood is given to the fetus to provide a better chance of survival from life threatening conditions associated with severe fetal anemia. It is an accepted method for the management of pregnancies, complicated with fetal haemolytic disease due to maternal red cell isoimmunization.
Blood transfusion is the process of transferring blood or blood products into one's circulation intravenously. Transfusions are used for various medical conditions to replace lost components of the blood. Lindenburg Irene T, Smits-Wintjens Vivianne E, van Klink Jeanine M, Verduin Esther, van Kamp Inge L, Walther Frans J, Schonewille Henk, Doxiadis Ilias I, Kanhai Humphrey H, van Lith Jan M, van Zwet Erik W, Oepkes Dick, Brand Anneke, Lopriore Enrico, Lopriore Enrico, Long-term neurodevelopmental outcome after intrauterine transfusion for hemolytic disease of the fetus/newborn: the LOTUS study. We found that a model combining abdominal circumference and gestational age did not result in a better prediction of the post-transfusion Hct than using either parameter on its own. In practice, most cases with Rhesus allo-immunisation in the UK will have an accurate estimate of gestational age based on early ultrasound.
Red blood cell (RBC) transfusions should usually be given only to restore or maintain oxygen delivery to vital organs and tissues. Medical history has clearly documented the importance of blood transfusion in saving lives threatened by acute haemorrhage or severe anaemia. Transfusion triggers in neonates are controversial and mainly based on expert clinical opinion, although recent randomised controlled trials of ‘liberal’ versus ‘restrictive’ red cell transfusion policies in very low birth weight preterm babies are starting to influence clinical guidelines. 10.2.1: Neonatal red cell exchange transfusion Intrauterine transfusion--intraperitoneal versus intravascular approach: a case-control comparison. Am J Obstet Gynecol 1990; 162:1053. Lewis M, Bowman JM, Pollock J, Lowen B. Absorption of red cells from the peritoneal cavity of an hydropic twin. and the associated risk of transfusion associated graft versus host disease (TA-GVHD), which may occur in immunosupressed patients, very small babies, in large volume transfusions and during intrauterine transfusions.5 Irradiation causes an increase in the rate of leakage of potassium out of RBCs during storage, and irradiated RBCs have a shortened